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Jianming Yu, Ph.D. Associate Professor, Department of Agronomy, Kansas State University will be addressing the topic “Opportunities and Challenges of Going Genome-Wid,” at the Danforth Center’s Fall Symposium on Thursday, September 29, 2011.
The focus of Dr. Yu's research is centered on complex trait dissection, identifying molecular variation underlying phenotypic variation. His research integrates knowledge in quantitative genetics, plant breeding, genomics, molecular genetics, and statistics with an ultimate goal of developing and applying new strategies and methods in trait dissection and crop improvement. His current research includes genome-wide association analysis with diverse germplasm or multiple designed mapping populations, genomic selection to efficiently integrate high throughput genotyping into pedigree breeding, gene cloning of traits with agronomic and domestication importance, and genome and chromosome evolution across taxonomic groups.
Opportunities and Challenges of Going Genome-Wide Advances in genomic technologies have made it possible to conduct genome-wide association study (GWAS) and genome-wide selection (GS). Dr. Yu will discuss while GWAS allows us to address some of the fundamental questions in genetic architecture of complex traits, GS facilitates the breeding of superior genotypes by maximizing gain per unit of time. However, many emerging challenges need to be addressed by a combination of genomic technology, functional analysis, genetic design, statistical and computational analysis, genome annotation, and gene network. Dr. Yu’s recently proposed composite resequencing-based GWAS (CR-GWAS) strategy and an Arabidopsis data set, he showed specifically how biological function predictions can be incorporated into the testing of rare variants and broadly how function prediction, genome database, and network information can be integrated into the process of identifying robust associations. In a second maize GWAS study, he found that both intragenic and intergenic polymorphisms contribute to the phenotypic variation of quantitative traits and trait-associated SNPs are enriched in the intergenic and promoter regions. The complex biological processes underlying complex traits ultimately present both challenges and opportunities of going genomewide.
In addition, Dr. Mark Tester, Professor of Plant Physiology, School of Agriculture, Food & Wine, University of Adelaide, based in the Australian Centre for Plant Functional Genomics; Director, Australian Plant Phenomics Facility will be speaking at the Symposium.
Dr. Tester led the establishment of the APPF, a $55m organization that develops and delivers state-of-the-art phenotyping facilities, including The Plant Accelerator, an innovative plant growth and analysis facility. He also leads a large academic research group using forward and reverse genetic approaches to understand salinity tolerance and nitrogen use efficiency, and how to improve this in crops such as wheat and rice.
Dr. Tester will discuss how he uses high throughput phenotyping to link plant genomes to phenomes Genetics and genomics are powerful tools for gene discovery, and increasingly efficient transgenic technologies are generating large numbers of GM crop plants.
To learn more about our 13th Annual Fall Symposium visit, http://www.danforthcenter.org/fall_symposium/. For the most up-to-date information, please follow us on Facebook & Twitter #FallSymposiumSTL.