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| Publications and Patents: |
|
Zhang J, Yu O (2008) Metabolic engineering of
isoflavone biosynthesis in seeds. In Modification of seed
composition to promote health and nutrition. Hari Krishnan (ed).
Agronomy Monograph Series, accepted. |
|
Cheng H, Yu O, Yu D (2008)
Polymorphisms of IFS genes are associated with isoflavone concentrations
in soybean seeds. Plant Science, in press.
|
Keyes CA, Subramanian S, Yu O (2008)
Hairy root as a model system for undergraduate laboratory curriculum and
research. Bioscene, accepted.
|
| Zhang J, Subramanian S, Stacey G, Yu O
(2008) Flavones and flavonols play distinct critical roles during
nodulation of Medicago truncatula by Sinorhizobium meliloti.
The Plant Journal, accepted. |
| Li L, He H, Zhang J, Wang X, Bai S, Stolc V,Tongprasit W, Young ND, Yu O, Deng XW (2008) Transcriptional analysis of highly syntenic regions between Medicago truncatula and Glycine max using tiling microarrays.
Genome Biology, 9: R57.
(http://genomebiology.com/2008/9/3/R57) |
| Graham TL, Graham MY, Yu O (2008)
Genomics of secondary metabolism in soybean. In Genetics and
genomics of Soybean. Gary Stacey (ed.), Springer, New York. pp. 211-242. |
| Yu O, Jez JM (2008) Nature's
assembly line: Biosynthesis of simple phenylpropanoids and polyketides.
Plant Journal 54: 750-762. |
Subramanian S, Fu Y, Sunkar R, Barbazuk WB, Zhu JK, Yu O (2008) Novel and nodulation-regulated microRNAs in soybean roots. BMC Genomics 9: 160 (http://www.biomedcentral.com/1471-2164/9/160).
Highly Accessed Article at BMCG.
|
| Schroeder AC, Kumaran S, Hicks LM, Cahoon RE, Halls C, Yu O, Jez JM (2008) Contributions of conserved serine and tyrosine residues to catalysis, ligand binding, and cofactor processing in the active site of tyrosine ammonia lyase. Phytochemistry 69: 1496-1506. |
Halls, C, Yu O (2008) Potential for metabolic engineering of resveratrol
biosynthesis. Trends in Biotechnology, 26:77-81.
|
Zhang J, Subramanian S, Zhang Y, Yu O (2007) Flavone synthases from Medicago
truncatula are flavanone-2-hydroxylases and are important for nodulation. Plant
Physiology 144: 741-751
|
Graham TL, Graham MY, Subramanian S, Yu O
(2007) RNAi silencing of genes for
elicitation or biosynthesis of 5-deoxyisoflavonoids suppresses race-specific
resistance and HR cell death in Phytophthora sojae infected tissues. Plant
Physiology 144: 724-740.
|
Subramanian S, Stacey G, Yu O (2007) Distinct, critical roles of flavonoids
during determinate and indeterminate legume nodulation. Trends in Plant Science
12: 282-285.
|
Chabaud M, Boisson-Dernier A, Zhang J, Taylor CG, Yu O, Barker DG (2006) Agrobacterium rhizogenes-mediated root transformation. In The Medicago
truncatula handbook. Ulrike Mathesius (ed),
http://www.noble.org/MedicagoHandbook/.
|
Subramanian S., Stacey G., Yu O (2006) Endogenous isoflavones are essential for
soybean-Bradyrhizobium japonicum interactions. Plant Journal 48: 261-273.
|
Zhang Y, Liu ZH, Jia L, Peng ZL, Jaworski J, Wang XM, Jez J., Chen F, Yu O
(2006) Metabolic engineering of de novo biosynthesis of resveratrol in
Saccharomyces cerevisiae and mammalian cells. Journal of American Chemistry
Society. 128: 13030-13031. Featured in Chemical and Engineering News, 84 (Oct.
2, 2006): page 43.
|
Ralston L, Yu O. (2006) Metabolons involving plant cytochrome P450s.
Phytochemistry Review. 5: 459-472.
|
Yu O. (2006) Metabolic engineering of the plant phenylpropanoid pathway.
Encyclopedia of Plant and Crop Science, Dekker Publishing. DOI:
10.1081/E-EPCS-120010589.
|
Yu O, Matsuno M, Subramanian S. (2006) Flavonoids in flowers: Genetics and
Biochemistry. In Floriculture, ornamental and plant biotechnology: Advances and
topical issues (1st Edition), Jaime A Teixeira da Silva (ed.), pp. 283-293.
|
Ralston L, Subramanian S, Matsuno M, Yu O. (2005) Partial reconstruction of flavonoid and isoflavonoid biosynthesis in yeast (Saccharomyces cerevisiae)
using soybean type I and type II chalcone isomerases. Plant Physiology 137:
1375-1388.
|
Subramainan S, Graham ML, Yu O, Graham T. (2005) Silencing of soybean isoflavone
synthase through an RNAi approach leads to silencing in non-transformed tissue
and to enhanced susceptibility to Phytophthora sojae. Plant Physiology 137:
1345-1353.
|
Yu O, McGonigle B. (2005) Metabolic engineering of isoflavone biosynthesis.
Advances in Agronomy 86: 147-189.
|
Bennett JO, Yu O, Heartherly LG, Krishnan HB. (2004). Accumulation of genistein
and daidzein, soybean isoflavones implicated in promoting human health, is
significantly elevated by irrigation. Journal of Agricultural and Food Chemistry
52: 7574-7579.
|
Subramanian S, Xu L, Lu G, Odell J, Yu O. (2004) The promoters of the isoflavone
synthase genes respond differentially to nodulation and defense signals in
transgenic soybean roots. Plant Molecular Biology 54:226-239.
|
Yu O, Shi J, Hession A, Maxwell C, McGonigle B, Odell J. (2003) Metabolic
engineering to increase isoflavone biosynthesis in soybean seed. Phytochemistry
63: 753-763
|
Yu O, Odell J. (2001) A method for altering the isoflavonoid profile in the seed
of an isoflavonoid-producing plant. US Patent No. 60/311461 (filed in June
2001), and 20060218672 (filed in Sept. 2006).
|
Odell J. Yu O, Hu X, G Lu (2001) Root-specific, stress inducible promoter and
its use. US Patent No. 7,196,247B2 (Issued: Mar. 27, 2007).
|
Yu O, Jung W, Shi J, Crose R, Fader G, McGonigle B, Odell J.
(2000) Production
of the isoflavones genistein and daidzein in non-legume dicot and monocot
tissues. Isoflavone accumulation is related to activity of the phenylpropanoid
pathway. Plant Physiology 124: 781-793.
|
Jung W, Yu O, Lau CSM, O'keefe DP, Odell J, Fader G, McGonigle B.
(2000) Identification and expression of isoflavone synthase, the key
enzyme for biosynthesis of isoflavones in legumes. Nature Biotechnology 18: 208-212.
|
Fader G, Jung W, McGonigle B, Odell J, Yu O. (1999) Nucleic acid fragments
encoding isoflavone synthease. WO 00/44909, US Patent No 7,098,011B1 (Issued:
Aug. 29, 2006).
|
Yu X, Sukumarian S, Marton L. (1998) Differential expression of the Arabidopsis
Nia1 and Nia2 genes. Plant Physiology 116: 1091-1096.
|
Yu X. (1998) Attempting homologous recombination in Arabidopsis by
positive-negative selections. Ph.D. Dissertation, University of South Carolina.
|
Czako M, Wilson J, Yu X, Marton L. (1993) Sustained root culture for generation
and vegetative propagation of transgenic Arabidopsis thaliana. Plant Cell
Reports 12: 603-606.
|
Zhang H, Gu F, Yu X, Song R. (1992) Effects of the characteristic of a click on
N1N2 response recorded from the round window in guinea pig. Acta Biophysica
Sinica. 8: 306-311.
|
Communications to Congresses
|
| Zhang J, Subramanian S, Stacey G, Yu O
(2008) Metabolic engineering of flavonoid biosynthesis revealed distinct
functions of flavonoids in legume-rhizobia interactions. Soy 2008,
Molecular & Cellular Biology of the Soybean Conference. Indianapolis,
IN. |
| Zhang J, Subramanian S, Stacey G, Yu O
(2008) Flavones and flavonols play distinct critical roles during
nodulation of Medicago truncatula by Sinorhizobium meliloti.
Banff Conference on Plant Metabolism, Banff, Alberta, Canada. |
| Graham MY, Sinden MR, Huge R, Subramanian,
S, Yu O, St Martin S, Graham TL (2008) Silencing of
defense-related genes reveals different mechanisms leading to
race-specific resistance to Phytophthora in soybean. APS Centennial
Meeting, Minneapolis, MN. |
| Zhang J, Subramanian S, Stacey G, Yu O
(2008) Flavones and flavonols play distinct critical roles during
nodulation of Medicago truncatula by Sinorhizobium meliloti.
Plant Biology 2008, Merida, Mexco. |
| Subramanian S, Fu Y, Sunkar R, Barbazuk B,
Zhu JK, Yu O (2008 Novel and nodulation-regulated microRNAs in
soybean roots. Plant Biology 2008, Merida, Mexco. |
Schroeder AC, Kumaran S, Hicks LM, Cahoon RE, Yu O, Jez J (2008) Contributions
of conserved serine and tyrosine residues to catalysis, ligand binding, and
cofactor processing in the active site of tyrosine ammonia lyase. Plant Biology
2008, Merida, Mexco.
|
Zhang J, Subramanian S, Yu O (2007) Flavone synthases from Medicago truncatula
are flavanone-2-hydroxylases and are important for nodulation. Plant Biology
2007, Chicago, IL. ASPB abstract.
|
Yamaguchi M, Valliyodan B, Zhang J, LeNoble ME, Yu O, Nguyen HT, Sharp RE (2007)
Proteomic analysis of the differential response of elongation rate to water
deficit within the soybean primary root growth zone. Plant Biology 2007,
Chicago, IL. ASPB abstract.
|
Halls C, Schroeder AC, Kumaran S, Cahoon RE, Jez JM, Yu O (2007) Metabolic
engineering of the red wine compound resveratrol. The ASA-CSSA-SSSA
International Annual Meetings, November, 2007, New Orleans, LA.
|
Graham TL, Graham MY, Subramanian S, Yu O (2007) Use of Gene Silencing and Metabolomics to Characterize Interactive Stress and Defense Pathways in Soybean.
3rd Cell Stress Society International Congress on Stress Responses in Biology
and Medicine. August 2007, Budapest, Hungary.
|
Gutierrez J, Sleper D, Nguyen HT, Valliyodan B, Yu O (2006) Genetic Analysis of isoflavone accumulation during soybean seed development under drought stress.
The ASA-CSSA-SSSA International Annual Meetings, November, 2006. Indianapolis,
IN.
|
Subramanian S, Stacey G, Yu O (2006) Endogenous isoflavones are essential for
the establishment of symbiosis between soybean and Bradyrhizobium japonicum.
Plant Roots: From Genes to Form & Function. Columbia, MO (Abstract 13).
|
Subramanian S, Stacey G, Yu O (2005)
Isoflavone's function in soybean
nodulation. Frontiers in Rhizosphere Research. Columbia, MO (Abstract 33).
|
Subramanian S, Matsuno M, Menne C, Ralston L, Yu O (2004) From transcriptional
regulation to metabolic channeling: understanding the flavonoid and isoflavonoid
pathway for metabolic engineering. Soy 2004. Columbia, MO (Abstract page 29).
|
Matsuno M, Ralston L, Subramanian S, Walker L, Yu O (2004) In vivo
reconstruction of flavonoid and isoflavonoid biosynthesis in yeast using type I
and type II chalcone isomerase from soybean. Plant Biology 2004. ASPB abstract
13003 and 267.
|
Subramanian S, Menne C, Odell J, Stacey G, Yu O (2004) Isoflavones are essential
for the establishment of symbiosis between soybean and Bradyrhizobium japonicum.
Plant Biology 2004. ASPB abstract 24003 and 591.
|
Matsuno M, Ralston L, Subramanian S, Walker L, Yu O (2004) In vivo
reconstruction of flavonoid and isoflavonoid biosynthesis in yeast. Gordon
Research Conference, Plant Molecular Biology 2004 poster, Plymouth, NH.
|
Ralston L, Subramanian S, Guo G, Menne C, Yu O (2003) Enzyme interactions in the isoflavonoid pathway. Fifth Annual Danforth Symposium. St Louis, MO.
|
Ralston L, Guo G, Yu O (2002) Metabolic engineering of isoflavonoid biosynthesis
in non-legume plants. First International Conference on Legume Genomics and
Genetics: Translation to Crop Improvement. Minneapolis-St. Paul, MN. (Abstract
K9)
|
Yu O, Shi J, Jung W, McGonigle B, Fader G, Odell J (2000) Metabolic engineering
of isoflavone synthesis in soybean and non-legume plants. Plant Physiology 2000.
ASPP Abstract
|
Yu X, Marton L (1998) Homologous gene replacement attempts in Arabidopsis by
positive-negative selections. Ninth International Conference on Arabidopsis
Research. (Abstract 122)
|
Yu X, Marton L (1997) Differencial regulation of the two nitrate reducase genes
in Arabidopsis. (Abstract 23). The Sixth South Carolina Statewide Research
Conference.
|
| Yu X, Sukumarian S, Marton L (1995) Remarkably higher frequency of
trans-inactivation of the Nia2 gene in the hemizygote than in the wild type
plants. (Abstract 793). Plant Physiol 108(S): 151. |
Marton L, Czako M, Wilson J, Marathe R, Sukumaran S, Yu X, Wenck A (1994)
Puzzling with homologous recombination in Arabidopsis. (abstract 31). Technology
transfer of plant biotechnology. The Fifth Gatlinburg Symposium, Knoxville,
Tennessee.
|
Yu X, Sukumaran S, Marton L (1994) Silencing Nia2 gene expression in transgenic
plants by transformation with nia2 homologous sequences in the T-DNA construct.
(abstract 55). The Fifth Gatlinburg Symposium, Knoxville, Tennessee.
|
Czako M, Marathe R, Wenck A, Sukumaran S, Yu X, Marton L (1993) Negative
selection by the HSV-thymidine kinase. (Abstract D16). The Second South Carolina
Statewide Research Conference.
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| Current Proposals |
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