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Proteomics & Mass Spectrometry

The Danforth Center’s Proteomics & Mass Spectrometry Facility develops new tools and provides high quality sample analysis in proteomics, mass spectrometry and related analytical fields.

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Facility News

Dr. Zhenjiu Liu receives an ABRF 2012 Poster Award!

Tuesday, March 20th, 2012

Waters Corporation sponsors prizes for the four best posters presented at ABRF 2012 that contain original research.

Congratulations Jen!!



New TripleTOF 5600 Installation – Super Exciting!!

Saturday, March 3rd, 2012

Q: How many people does it take to uncrate one TripleTOF 5600?

Step 1

Step 2

Step 3

Home Sweet Home!!



Welcome to Silas Rodrigues and Brian Gau –two new postdoctoral scientists in the Hicks Lab!!!

Monday, January 16th, 2012

Brian Gau

Silas Rodrigues



Dr. Hicks was promoted to an Assistant Member and Principal Investigator at the Danforth Center!!!

Sunday, January 1st, 2012

Dr. Leslie Hicks was promoted to Assistant Member effective January 1, 2012 and will focus on technology development, the sustainable production of biofuels, and understanding the consequences of oxidative stress.  For the last five years she served as the Director of the Danforth Center’s Proteomics and Mass Spectrometry Facility, which provides critical services in proteomics, metabolomics and related analytical fields.   Her research program focuses on development and implementation of approaches for protein characterization including post-translational modifications, as well as the identification of bioactive peptides/proteins from plants.  Dr. Hicks earned her Ph.D. in Analytical Chemistry from the  University of Illinois, Urbana-Champaign.

To read more click here



PNAS Celebration Picnic

Monday, July 26th, 2010

Lab celebrates PNAS Publication on Cucurbits by picnicking at Rend Lake. Menu included: Cucumber salad, Grilled Zucchini, Pumpkin Pie and Watermelon. Mmmm!! Despite rain early in the day, it turned out to be an excellent day for boating/tubing!!



Publication News: Drs. Baichen Zhang and Leslie M. Hicks publish “Divergent metabolome and proteome suggest functional independence of dual phloem transport systems in cucurbits” in PNAS

Tuesday, June 22nd, 2010

Find out more by reading Press Release

Link to publication in PNAS

Image below: Atlantic Giant pumpkin grown by Greg Dulski (Illinois Giant Pumpkin Growers Association, Hoffman Estates, IL) and used for phloem protein analysis in the PNAS publication.



DOE Secretary Steven Chu Visits PMSF

Friday, May 21st, 2010

Chu Visits Danforth

On May 21, U.S. Department of Energy Secretary Steven Chu paid a visit to the Donald Danforth Plant Science Center to learn about the progress of our research on biofuels and the Enterprise Rent-A-Car Institute for Renewable Fuels.

This isn’t the first time the Danforth Center has attracted the attention of the Department of Energy. In January, the Secretary announced that The National Alliance for Advanced Biofuels and Bioproducts (NAABB), led by the Donald Danforth Plant Science Center, had been selected to receive $48 million from DOE under the American Recovery and Reinvestment Act. This consortium is conducting advanced biofuels research to support the development of a clean and sustainable transportation sector. Additionally, the DOE had designated the Danforth Center in 2009 as an Energy Frontier Research Centers and provided a $15 million, five-year award to establish a Center for Advanced Biofuels Systems (CABS).

During Secretary Chu’s visit, Danforth Center Chairman Dr. William H. Danforth greeted him and provided an overview of the Center’s mission and vision, which is “to improve the human condition through plant science.” Dr. Richard Sayre, Director of the ERAC Institute also provided and in-depth overview of the Center’s research on algal biofuels. Following the formal briefings, the Secretary visited the Center’s Proteomics and Mass Spectrometry facility where Dr. Leslie Hicks gave him a tour and first-hand look at the valuable instruments that are integral to this research.

Before leaving, Secretary Chu stopped by the lab of Dr. Sam Wang to learn more about the Center For Advanced Biofuels project that aims to increase the thermodynamic and kinetic efficiency for select plant and algal based fuel production systems.



Dr. Sophie Alvarez, Facility Manager, receives ABRF Outstanding Scientists and Technologists Travel Award

Saturday, March 20th, 2010



Proteomics & Mass Spectrometry Facility receives $870K NSF-MRI Grant: Acquisition of LTQ-Orbitrap High Resolution Mass Spectrometer (PI: Leslie M. Hicks)

Tuesday, September 1st, 2009



DDPSC Investigators awarded $15M from DOE to establish Center for Advanced Biofuels Systems (CABS) (co-PI: Leslie M. Hicks)

Monday, April 27th, 2009

DANFORTH PLANT SCIENCE CENTER AWARDED $15 MILLION FROM US DEPARTMENT OF ENERGY TO ESTABLISH ENERGY FRONTIER RESEARCH CENTER

ST. LOUIS, MO April 27, 2009—The Donald Danforth Plant Science Center will be home to one of 46 new multi-million-dollar Energy Frontier Research Centers (EFRCs) announced yesterday by the White House in conjunction with a speech delivered by President Barack Obama at the annual meeting of the National Academy of Sciences. The EFRCs, which will pursue advanced scientific research on energy, are being established by the U.S. Department of Energy Office of Science at universities, national laboratories, nonprofit organizations, and private firms across the nation.

As an EFRC the Danforth Plant Science Center will receive $15 million over a five year period to establish a Center for Advanced Biofuels Systems (CABS) which will be led by Richard Sayre, PhD who will serve as Director. Sayre is also the director of the Enterprise Rent-A-Car Institute for Renewable Fuels at the Danforth Center. The team of principal investigators from the Danforth Center include Drs. Jan Jaworski, Sam Wang, Toni Kutchan, Oliver Yu, Leslie Hicks, as well as Ed Cahoon of the University of Nebraska-Lincoln, David Gang of the University of Arizona and Yair Shachar-Hill of Michigan State University.

The objective of the Center for Advanced Biofuel Systems is to increase the thermodynamic and kinetic efficiency for select plant and algal based fuel production systems. A unique feature of the Danforth Center’s approach is the integration of all aspects of plant metabolism from photosynthesis to the synthesis and accumulation of oils and novel biofuels products. This “systems” approach will bring new and emerging technologies to bear on complex problems and will improve biofuel production and product development.

“The EFRC award will allow us to transition basic research on algal and plant-based biofuel systems into sustainable energy production systems for the future,” said Sayre.

“As global energy demand grows over this century, there is an urgent need to reduce our dependence on fossil fuels and imported oil and curtail greenhouse gas emissions,” said Secretary of Energy Steven Chu. “Meeting this challenge will require significant scientific advances. These Centers will mobilize the enormous talents and skills of our nation’s scientific workforce in pursuit of the breakthroughs that are essential to make alternative and renewable energy truly viable as large-scale replacements for fossil fuels.”

The 46 EFRCs, to be funded at $2-5 million per year each for a planned initial five-year period, were selected from a pool of some 260 applications received in response to a solicitation issued by the U.S. Department of Energy Office of Science in 2008. Selection was based on a rigorous merit review process utilizing outside panels composed of scientific experts.

EFRC researchers will take advantage of new capabilities in nanotechnology, high-intensity light sources, neutron scattering sources, supercomputing, and other advanced instrumentation, much of it developed with DOE Office of Science support over the past decade, in an effort to lay the scientific groundwork for fundamental advances in solar energy, biofuels, transportation, energy efficiency, electricity storage and transmission, clean coal and carbon capture and sequestration, and nuclear energy.

Of the 46 EFRCs selected, 31 are led by universities, 12 by DOE National Laboratories, two by nonprofit organizations including the Danforth Center, and one by a corporate research laboratory. The criterion for providing an EFRC with Recovery Act funding was job creation. The EFRCs chosen for funding under the Recovery Act provide the most employment for postdoctoral associates, graduate students, undergraduates, and technical staff, in keeping with the Recovery Act’s objective to preserve and create jobs and promote economic recovery.
About The Donald Danforth Plant Science Center
Founded in 1998, the Donald Danforth Plant Science Center is a not-for-profit research institute with a global vision to improve the human condition. Research at the Danforth Center will enhance the nutritional content of plants to improve human health, increase agricultural production to create a sustainable food supply, and build scientific capacity to generate economic growth in the St. Louis region and throughout Missouri. For more information please visit www.danforthcenter.org.