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Click here
for
Dr. Toni Kutchan's List
Click here for
Dr. Meinhart Zenk's List
Some reprints are available at the
links below. Please note that subscriptions are needed to access
some of these reprints.
Toni M. Kutchan Selected
representative publications:
Kutchan, T.M., Hampp, N., Lottspeich, F., Beyreuther, K. and Zenk, M.H.
The cDNA clone for strictosidine synthase from Rauvolfia serpentina: DNA
sequence determination and expression in Escherichia coli. FEBS Lett.
237, 40-44 (1988).
Link to abstract/article
Dittrich, H. and Kutchan, T.M. Molecular cloning, expression and
induction of berberine bridge enzyme, an enzyme essential to the
formation of benzophenanthridine alkaloids in the response of plants to
pathogenic attack. Proc. Natl. Acad. Sci. USA 88, 9969-9973 (1991).
Link to abstract/article
Kraus, P.F.X. and Kutchan, T.M. Molecular cloning and heterologous
expression of a cDNA encoding berbamunine synthase, a C-O
phenol-coupling cytochrome P-450 from the higher plant Berberis
stolonifera. Proc. Natl. Acad. Sci. USA 92, 2071-2075 (1995).
Link to abstract/article
Kutchan, T.M. and Dittrich, H. Characterization and mechanism of the
berberine bridge enzyme, a covalently flavinylated oxidase of
benzophenanthridine alkaloid biosynthesis in plants. J. Biol. Chem. 270,
24475-24481 (1995).
Link to abstract/article
Pauli, H.H. and Kutchan, T.M. Molecular cloning and functional
heterologous expression of two alleles encoding (S)-N-methylcoclaurine
3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome
P-450 dependent monooxygenase of benzylisoquinoline alkaloid
biosynthesis. Plant J. 13, 793-801 (1998).
Link to abstract/article
Unterlinner, B., Lenz, R. and Kutchan, T.M. Molecular cloning and
functional expression of codeinone reductase - the penultimate enzyme in
morphine biosynthesis in the opium poppy Papaver somniferum. Plant J.
18, 465-475 (1999).
Link to abstract/article
Grothe, T., Lenz, R. and Kutchan, T.M. Molecular characterization of the
salutaridinol 7-O-acetyltransferase involved in morphine biosynthesis in
opium poppy Papaver somniferum. J. Biol. Chem. 276, 30717-30723 (2001).
Link to abstract/article
Weid, M., Ziegler, J. and Kutchan, T.M. The roles of latex and the
vascular bundle in morphine biosynthesis in the opium poppy Papaver
somniferum. Proc. Natl. Acad. Sci. USA, 101, 13957-13962 (2004).
Link to abstract/article
Ziegler, J., Diaz-Chavez, M.L., Kramell, R., Ammer, C. and Kutchan, T.M.
Comparative macroarray analysis of morphine containing Papaver
somniferum and eight morphine free Papaver species identifies an
O-methyltransferase
involved in benzylisoquinoline biosynthesis. Planta 222, 458 - 471
(2005).
Link to abstract/article
Ziegler, J., Voigtlaender, S., Schmidt, J., Kramell, R., Miersch, O.,
Ammer, C., Gesell, A., and Kutchan, T.M. Comparative transcript and
alkaloid profiling in Papaver species identifies a short chain
dehydrogenase / reductase involved in morphine biosynthesis. Plant J.
48, 177-192 (2006).
Link to abstract/article
Winkler, A., Kutchan, T.M., Anton Glieder, A., and Macheroux, P.
Berberine bridge enzyme possesses a novel bi-covalently attached FAD
cofactor linked to a histidine and cysteine residue. J. Biol. Chem. 281,
21276-21285 (2006).
Link to abstract/article
Winkler, A., Kutchan, T.M. and Macheroux, P. 6-S-Cysteinylation of
bi-covalently attached FAD in berberine bridge enzyme tunes the redox
potential for optimal activity J. Biol. Chem. 282, 24437-24443 (2007).
Link to abstract/article
Springob, K., Samappito, S., Jindaprasert, A., Schmidt, J., Page, J.E.,
De-Eknamkul, W. and Kutchan, T.M. A polyketide synthase of Plumbago
indica that catalyzes the formation of a hexaketide pyrone. FEBS J. 274,
406-417 (2007).
Link to abstract/article
Larkin, P.J., Miller, J., Allen, R.S., Millgate, A.G., Chitty, J.A.,
Gerlach, W.L., Frick, S., Kutchan, T.M. and Fist, A.J. Increasing
morphinan alkaloid production by overexpressing codeinone reductase in
transgenic Papaver somniferum. Plant Biotech. J. 5, 26-37
(2007).
Link to abstract/article
Frick, S., Kramell, R. and Kutchan, T.M. Metabolic engineering of a
morphine biosynthetic P450 in opium poppy surpasses breeding. Metabolic
Engineering 9, 169-176 (2007).
Link to abstract/article
Meinhart H. Zenk selected
representative publications:
Nagakura, N., Rueffer, M., Zenk, M. H. (1979): "The biosynthesis of
monoterpenoid indole alkaloids from strictosidine." Journal of the
Chemical Society, Perkin Transactions 1: Organic and Bio-Organic
Chemistry (1972-1999): 2308-2312.
Link to abstract/article
Grill, E., Winnacker, E. L., Zenk, M. H. (1985): "Phytochelatins: the
principal heavy-metal complexing peptides of higher plants." Science
230: 674-676.
Link to abstract/article
Streber, W. R., Timmis, K. N., Zenk, M. H. (1987): "Analysis, cloning,
and high-level expression of 2,4-dichlorophenoxyacetate monooxygenase
gene tfdA of Alcaligenes eutrophus JMP134." J. Bacteriol. 169:
2950-2955.
Link to abstract/article
Zenk, M. H., Gerardy, R., Stadler, R. (1989): "Phenol oxidative coupling
of benzylisoquinoline alkaloids is catalyzed by region- and
stereo-selective cytochrome P450 linked plant enzymes: salutaridine and
berbamunine." J. Chem. Soc., Chem. Commun. 22: 1725-1727.
Link to abstract/article
Stadler, R., Zenk, M. H. (1990): "A revision of the generally accepted
pathway for the biosynthesis of the benzyltetrahydroisoquinoline
alkaloid reticuline." Liebigs Ann. Chem.: 555-562.
Link to abstract/article
Gundlach, H., Mueller, M. J., Kutchan, T. M., Zenk, M. H. (1992): "Jasmonic
acid is a signal transducer in elicitor-induced plant cell cultures."
Proceedings of the National Academy of Sciences of the United States of
America 89: 2389-2393.
Link to abstract/article
Lotter, H., Gollwitzer, J., Zenk, M. H. (1992): "Revision of the
configuration at C-7 of salutaridinol-I, the natural intermediate in
morphine biosynthesis." Tetrahedron Lett. 33: 2443-2446.
Link to abstract/article
Lenz, R., Zenk, M. H. (1995): "Acetyl coenzyme
A:salutaridinol-7-O-acetyltransferase from Papaver somniferum plant cell
cultures. The enzyme catalyzing the formation of thebaine in morphine
biosynthesis." J. Biol. Chem. 270: 31091-31096.
Link to abstract/article
Zenk, M. H. (1996): "Heavy metal detoxification in higher plants - a
review." Gene 179: 21-30.
Link to abstract/article
Eisenreich, W., Schwarz, M., Cartayrade, A., Arigoni, D., Zenk, M. H.,
Bacher, A. (1998): "The deoxyxylulose phospate pathway of terpenoid
biosynthesis in plants and microorganisms." Chem. Biol. 5: R221-R233.
Link to abstract/article
Raith, K., Neubert, R., Poeaknapo, C., Boettcher, C., Schmidt, J., Zenk,
M. H. (2003): "Electrospray tandem mass spectrometric investigations of
morphinans." Am. Soc. Mass Spectr. 14: 1262-1269.
Link to abstract/article
Poeaknapo, C., Schmidt, J., Brandsch, M., Draeger, B., Zenk, M. H.
(2004): "Endogenous formation of morphine in human cells." Proceedings
of the National Academy of Sciences of the United States of America 101:
14091-14096.
Link to
abstract/article
Boettcher, C., Fellermeier, M., Boettcher, C., Draeger, B., Zenk, M. H.
(2005): "How human neuroblastoma cells make morphine." Proceedings of
the National Academy of Sciences of the United States of America 102:
8495-9500.
Link to abstract/article
Nikolaev, V. O., Boettcher, C., Dees, C., Buenemann, M., Lohse, M. J.,
Zenk, M. H. (2007): "Live cell monitoring of mu-opioid receptor-mediated
G-protein activation reveals strong biological activity of close
morphine biosynthetic precursors." J. Biol. Chem. 282: 27126-27132.
Link to abstract/article
Schmidt, J., Boettcher, C., Kuhnt, C., Kutchan, T. M., Zenk, M. H.
(2007): "Poppy alkaloid profiling by electrospray tandem mass
spectrometry and electrospray FT-ICR mass spectrometry after
[ring-13C6]-tyramine feeding." Phytochemistry 68: 189-202.
Link to abstract/article
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