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Publications
Click on a
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Washington University (2008-Present)
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63. He Y, Mawhinney TP, Preuss
ML, Schroeder AC, Chen B, Abraham L, Jez JM, Chen S
(2009) A redox active isopropylmalate dehydrogenase
functions in the biosynthesis of glucosinolates and
leucine in Arabidopsis. Plant J. (in press) |
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62. Chen Q, Zhang B, Hicks LM, Wang S, Jez JM
(2009) A liquid chromatography-tandem mass
spectrometry-based assay for indole-3-acetic acid-amido
synthetases. Anal. Biochem. 390, 149-154 |
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61. Jez JM, Krishnan HB (2009)
Sulfur assimilation and cysteine biosynthesis in
soybean seeds: towards engineering sulfur amino acid
content In Modification of Seed Composition to
Promote Health and Nutrition (Krishnan HB, Ed.), pp.
249-262, ASA-CSSA-SSSA Publishing, Madison, WI |
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60. Alvarex S, Berla BM, Sheffield J, Cahoon RE,
Jez JM, Hicks LM (2009) Comprehensive analysis of
the Brassica juncea root proteome in response to
cadmium exposure by complementary proteomic
approaches. Proteomics 9, 2419-2431 |
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59. Yi H, Preuss ML, Jez JM
(2009) The devil (and an active jasmonate hormone)
are in the details. Nature Chem. Biol. 5, 273-274 |
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58. Kumaran S, Yi H, Krishnan
HB, Jez JM (2009) Assembly of the cysteine synthase
complex and the regulatory role of protein-protein
interactions. J. Biol. Chem. 284, 10268-10275 |
Donald Danforth Plant
Science Center (2002-Present)
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57. Jez JM, Fukagawa NK (2008) Plant
sulfur compounds and human health In
Sulfur: A Missing Link Between Soils,
Crops, and Nutrition (Jez
JM, Ed.), pp. 281-292, ASA-CSSA-SSSA Publiishing, Madison, WI |
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56. Yu O, Jez JM (2008) Nature's
assembly line: biosynthesis of simple phenylpropanoids and
plant polyketides. Plant J.
54, 750-762
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55. Schroeder AC, Kumaran S, Hicks LM,
Cahoon RE, Halls C, Yu O, Jez JM (2008) Contributions of
conserved serine and tyrosine residues to catalysis, ligand
binding, and cofactor processing in the active site of
tyrosine ammonia lyase.
Phytochemistry 69,
1496-1506
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54. Arkus
KAJ, Jez JM (2008) An integrated protein chemistry lab
module: choloropyll and chlorophyllase.
Biochem. Mol. Biol. Educ.
36,125-128
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53. Zubieta C, Arkus KAJ, Cahoon
RE, Jez JM (2008) A single amino acid change is responsible
for evolution of acyltransferase specificity in bacterial
methionine biosynthesis.
J. Biol. Chem.
283, 7561-7567
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52. Kumaran S, Francois JA,
Krishnan HB, Jez JM (2008) Regulatory protein-protein
interactions in primary metabolism: the case of the cysteine
synthase complex In Sulfur
Assimilation and Abiotic Stress in Plants
(NA Khan, RP Singh, Eds), pp. 97-109, Springer-Verlag, NY
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51. Phartiyal P, Kim WS, Cahoon
RE, Jez JM, Krishnan HB (2008) The role of
5’-adenylylsulfate reductase in the sulfur assimilation
pathway of soybean: molecular cloning, gene
expression, and kinetic characterization.
Phytochemistry 69,
356-364
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50. Jez
JM, Schachtman DP, Berg RH, Taylor CG, Chen S, Hicks LM,
Jaworski JG, Smith TJ, Nielsen E, Pikaard CS (2007)
Developing a new interdisciplinary lab course for
undergraduate and graduate students: plant cells and
proteins.
Biochem. Mol. Biol. Educ.
35, 410-415
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49. Hicks LM, Cahoon RE, Bonner ER, Rivard RS, Sheffield J,
Jez JM (2007) Thiol-based regulation of redox-active
glutamate-cysteine ligase from Arabidopsis thaliana.
Plant Cell 19, 2653-2661 |
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48.
Herrera K, Cahoon RE, Kumaran S, Jez JM (2007) Reaction
mechanism of glutathione synthetase from Arabidopsis
thaliana: site-directed mutagenesis of active site
residues. J. Biol. Chem. 282,
17157-17165 |
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47. Fu CJ, Jez JM, Kerley MS,
Allee GL, Krishnan HB (2007) Identification,
characterization, epitope mapping, and three-dimensional
modeling of alpha-subunit of beta-conglycinin of soybean, a
potential allergen for young pigs. J. Agric. Food Chem.
55, 4014-4020 |
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46. Kumaran S, Jez JM (2007) Thermodynamics of the interaction
between O-acetylserine sulfhydrylase and the C-terminus of
serine acetyltransferase.
Biochemistry 46, 5586-5594 |
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45. Shin R, Alvarez S, Burch AY, Jez JM, Schachtman DP (2007)
Phosphoproteomic identification of targets of the
Arabidopsis sucrose nonfermenting-like kinase
SnRK2.8 reveals a connection to metabolic processes.
Proc. Natl. Acad. Sci. USA 104, 6460-6465 |
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44. Brendza KM, Haakenson W, Cahoon RE, Hicks LM, Palavalli
LH, Chiapelli B, McLaird M, McCarter JP, Williams DJ, Hresko
MC, Jez JM (2007) Phosphoethanolamine N-methyltransferase
(PMT-1) catalyzes the first reaction of a new pathway for
phosphocholine biosynthesis in Caenorhabditis elegans.
Biochem. J. 404, 439-448 |
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43. Jez JM (2007) Phosphatidylcholine biosynthesis as a
potential target for inhibition of metabolism in parasitic
nematodes. Curr. Enz. Inhib. 3, 133-142 |
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42. Francois JA, Kumaran S, Jez JM (2006) Structural basis for
interaction of O-acetylserine sulfhydrylase and serine
acetyltransferase in the Arabidopsis cysteine synthase
complex. Plant Cell 18, 3647-3655 |
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41. Zhang Y, Li SZ, Pan X, Cahoon RE, Jaworski JG, Wang X, Jez
JM, Chen F, Yu O (2006) Using unnatural protein fusions to
engineer resveratrol biosynthesis in yeast and mammalian
cells. J. Am. Chem. Soc.
128, 13030-13031 |
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40. Romanyuk ND, Rigden DJ, Vatamaniuk OK, Lang A, Cahoon RE,
Jez JM, Rea PA (2006) Mutagenic definition of papain-like
catalytic triad and sufficiency of N-terminal domain for
single-site enzyme acylation and core catalysis by an
eukaryotic phytochelatin synthase. Plant Physiol.
141, 858-869 |
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39. Phartiyal P, Kim WS, Cahoon RE, Jez JM, Krishnan HB (2006)
Soybean ATP sulfurylase, a homodimeric enzyme involved in
sulfur assimilation, is abundantly expressed in roots and
induced by cold treatment. Arch. Biochem. Biophys.
450, 20-29 |
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38. Arkus KAJ, Jez JM (2006) Development of a high-throughput
purification method and a continuous assay for
chlorophyllase. Anal. Biochem. 353, 93-98
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37. Palavalli LH, Brendza KM, Haakenson W, Cahoon RE, McLaird
M, Hicks LM, McCarter JP, Williams DJ, Hresko MC, Jez JM
(2006) Defining the role of phosphomethylethanolamine
N-methyltransferase from Caenorhabditis elegans in
phosphocholine biosynthesis by biochemical and kinetic
analysis. Biochemistry 45, 6056-6065
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36. Bonner ER, Cahoon RE, Knapke SM, Jez JM (2005) Molecular
basis of plantcysteine biosynthesis: structural and
functional analysis of O-acetylserinesulfhydrylase from
Arabidopsis thaliana. J. Biol. Chem. 280: 38803-38813
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35.
Arkus KAJ, Cahoon EB, Jez JM (2005)
Mechanistic analysis of wheat
chlorophyllase. Arch. Biochem.
Biophys.
438, 146-155 |
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34. Jez JM, Cahoon RE (2004) Kinetic mechanism of glutathione
synthetase from
Arabidopsis
thaliana. J.
Biol. Chem. 279, 42726-42731 |
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33. Jez JM, Cahoon RE, Chen S (2004) Arabidopsis thaliana
glutamate-cysteine ligase: functional properties, kinetic
mechanism, and regulation of activity.
J.
Biol. Chem. 279, 33463-33470 |
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Kosan
Biosciences, Inc. (2001-2002)
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32. Jez JM, Chen JC, Rastelli J, Stroud RM, Santi DV (2003) Crystal structure and
molecular modeling of 17-DMAG in complex with the N-terminal domain of human hsp90. Chem. Biol
10, 361-368 |
Post-doctoral work (Salk Institute 1998-2001)
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31. Jez JM, Bowman ME, Noel JP (2002) Expanding the biosynthetic repertoire of type
III polyketide synthases by altering starter molecule specificity. Proc. Natl. Acad.Sci. USA 99, 5319-5324 |
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30. Jez JM, Bowman ME, Noel JP (2002) The role of hydrogen bonds in the reaction
mechanism of chalcone isomerase. Biochemistry 41, 5168-5176 |
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29. Jez JM, Noel JP (2002) Reaction mechanism of chalcone isomerase: pH- dependence, diffusion control, and product binding differences. J. Biol. Chem. 277, 1361-1369 |
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28. Noel JP, Jez JM, Austin MB, Bowman ME, Ferrer JL (2002) Structurally guided
alteration of biosynthesis in plant type III polyketide synthases in Recent Advances in Phytochemistry Vol. 36 – Phytochemistry in the Genomics and Post-Genomics Era (JT Romeo, ed.) pp. 197-222, Plenum Press, New York |
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27. Jez JM, Ferrer JL, Bowman ME, Austin MB, Schröder J, Dixon RA, Noel JP (2001) Structure and mechanism of chalcone synthase-like polyketide synthases. J. Ind. Micro. Biotech. 27, 393-398 |
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26. Jez JM, Bowman ME, Noel JP (2001) Structure-guided programming of polyketide chain-length determination in chalcone synthase. Biochemistry 49, 14829- 14838 |
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25. Mallis RJ, Bruzin K, Jez JM, Wilson EK, Dieckmann GR, Robic S, Harrahy J (2001) Proteins: the complete works. Trends Biochem. Sci. 26, 642-643 |
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24. Penning TM, Jez JM (2001) Enzyme redesign. Chem. Rev. 101, 3027-3046 |
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23. Jez JM, Noel JP (2000) Mechanism of chalcone synthase: pKa of the catalytic cysteine and the role of the conserved histidine in a plant-specific polyketide synthase. J. Biol. Chem. 275, 39640-39646 |
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22. Jez JM, Austin MB, Ferrer J-L, Bowman ME, Schröder J, Noel JP (2000) Structural control of polyketide formation in plant-specific polyketide synthases. Chem. Biol. 7, 919-930 |
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21. Jez JM, Bowman ME, Dixon RA, Noel JP (2000) Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nature Struct. Biol. 7, 786-791 |
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20. Jez JM, Noel JP (2000) A kaleidoscope of carotenoids. Nature Biotech. 18, 825- 826 |
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19. Jez JM, Ferrer J-L, Bowman ME, Dixon RA, Noel JP (2000) Dissection of malonyl-CoA decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry 39, 890-902 |
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18. Ferrer J-L, Jez JM, Bowman ME, Dixon RA, Noel JP (1999) Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Nature Struct. Biol. 6, 775-784 |
Graduate work (University of Pennsylvania, 1992-1998)
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17. Penning TM, Ma H, Jez JM (2001) Engineering steroid hormone specificity into aldo-keto reductases. Chem. Biol. Interact. 130-132, 659-671 |
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16. Jez JM, Penning TM (2001) The aldo-keto reductase superfamily: an update. Chem. Biol. Interact. 130-132, 499-525 |
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15. Penning TM, Burczynski ME, Jez JM, Lin H-K, Ma H, Moore M, Ratnam K, Palackal N (2001) Structure-function aspects and inhibitor design of type 5 17ß- hydroxysteroid dehydrogenase (AKR1C3). Mol. Cell. Endocrinol. 171, 137-149 |
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14. Penning TM, Burczynski ME, Jez JM, Hung C-F, Lin H-K, Ma H, Moore M, Palackal N, Ratnam K (2000) Human 3a-hydroxysteroid dehydrogenase isoforms (AKR1C1-1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation sex hormones. Biochem. J. 351, 67-77 |
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13. Jez JM, Penning TM (1998) Engineering steroid 5ß-reductase activity into rat liver 3a-hydroxysteroid dehydrogenase. Biochemistry 37, 9695-9703 |
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12. Schlegel BP, Jez JM, Penning TM (1998) Mutagenesis of 3a-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases. Biochemistry 37, 3538-3548 |
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11. Penning TM, Lin H-K, Jez JM, Ricigliano JW (1997) Inhibition of type 3 3a-hydroxysteroid dehydrogenase in Emerging Therapeutic Targets, Vol. 1: Oncologic, Endocrine, & Metabolic (A Ward, ed.) pp. 141-145, Ashley Publications Ltd., London |
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10. Jez JM*, Lin H-K*, Schlegel BP, Peehl DM, Pachter JA, Penning TM (1997) Expression and characterization of recombinant type 2 3a-hydroxysteroid dehydrogenase from human prostate: Demonstration of bifunctional 3a/17ß-HSD activity and cellular distribution. Mol. Endocrinol. 11, 1971-1984 (*equal contribution) |
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9. Jez JM, Flynn TG, Penning TM (1997) A new nomenclature for the aldo-keto reductase superfamily. Biochem. Pharmacol. 54, 639-647 |
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8. Jez JM, Bennett MJ, Schlegel BP, Lewis M, Penning TM (1997) Comparative anatomy of the aldo-keto reductase superfamily. Biochem. J. 326, 625-636 |
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7. Bennett MJ, Albert RH, Jez JM, Ma H, Penning TM, Lewis M (1997) Steroid recognition and regulation of hormone action: structure of testosterone and NADP+ bound to 3a-hydroxysteroid/dihydrodiol dehydrogenase. Structure 5, 799-812 |
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6. Penning TM, Bennett MJ, Smith-Hoog S, Schlegel BP, Jez JM, Lewis M (1997) Structure and function of rat 3a-hydroxysteroid dehydrogenase. Steroids 62, 101-111 |
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5. Jez JM, Flynn TG, Penning TM (1996) A proposed nomenclature system for the aldo-keto reductase superfamily in Enzymology and Molecular Biology of Carbonyl Metabolism 6 (H Weiner, R Lindahl, DW Crabb, & TG Flynn, eds.) pp. 579-589, Plenum Press, New York |
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4. Jez JM, Schlegel BP, Penning TM (1996) Characterization of the substrate binding pocket in rat liver 3a-hydroxysteroid/dihydrodiol dehydrogenase: the roles of tryptophans in ligand recognition and protein fluorescence. J. Biol. Chem. 271, 30190-30198 |
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3. Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M (1996) Structure of 3a-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+. Biochemistry 35, 10702-10711 |
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2. Penning TM, Pawlowski JE, Schlegel BP, Jez JM, Lin H-K, Hoog SS, Bennett MJ, Lewis M (1996) Mammalian 3a-hydroxysteroid dehydrogenases. Steroids 61, 508-523 |
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1. Jez JM, Vanderkooi JM, Laties AM (1996) Spectroscopic characterization of bendazac and benzydamine: possible photochemical modes of action. Biochem. Biophys. Res. Comm. 221, 266-270 |
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