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Ed Cahoon's Laboratory








 
      
Publications

Cahoon EB, Shockey JM, Dietrich CR, Gidda SK, Mullen RT, Dyer JM (2007) Engineering
oilseeds for sustainable production of industrial and nutritional feedstocks: solving bottlenecks in
fatty acid flux. Curr. Opin. Plant. Biol. 10: 236-244

Hunter SC, Cahoon EB (2007) Enhancing vitamin E in oilseeds: unraveling tocopherol and
tocotrienol biosynthesis. Lipids 42: 97-108.

Chen M, Han G, Dietrich CR, Dunn TM, Cahoon EB (2006) The essential nature of
sphingolipids in plants as revealed by the functional identification and characterization of the
Arabidopsis LCB1 subunit of serine palmitoyltransferase. Plant Cell 18: 3576-3593.

Lohman A, Schottler MA, Brehelin C, Kessler F, Block R, Cahoon EB, Dörmann P (2006)
Deficiency in phylloquinone (vitamin K1) methylation affects prenylquinine distribution,
photosystem I abundance and anthocyanin accumulation in the Arabidopsis AtmenG mutant. J.
Biol. Chem. 281: 40461-40472.

Kaewsuwan S, Cahoon EB, Perroud P-F, Wiwat C, Panvisavas N, Quatrano RS, Cove DJ,
Bunyapraphatsaran N (2006) Identification and functional characterization of the moss
Physcomitrella patens (Hedw.) B.S.G. .5-desaturase gene involved in arachidonic and
eicosapentaenoic acids biosynthesis. J. Biol. Chem. 281:21988-21997.

Cahoon EB, Dietrich CR, Meyer K, Damude HG, Dyer JM, Kinney AJ (2006) Conjugated fatty
acids accumulate to high levels in phospholipids of metabolically engineered soybean and
Arabidopsis seeds. Phytochemistry 67: 1166-1176.

Markham JM, Li J, Cahoon EB, Jaworski JG (2006) Plant sphingolipids: separation and
identification of major sphingolipid classes from leaves. J. Biol. Chem. 281: 22684-94.

Eckert H, LaVallee B, Schweiger BJ, Kinney AJ, Cahoon EB, Clemente T (2006) Co-expression
of the borage .6 desaturase and the Arabidopsis .15 desaturase results in high accumulation of
stearidonic acid in the seeds of transgenic soybean. Planta 224: 1116-1128.

Paul S, Gable K, Beaudoin F, Cahoon E, Jaworski J, Napier JA, Dunn TM (2006)
Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family substitute for the
elop proteins of Saccharomyces cerevisiae. J. Biol. Chem. 281: 9018-9029.

Whittle E, Cahoon EB, Subrahmanyam S, Shanklin J (2005) A multifunctional acyl-acyl carrier
protein desaturase from Hedera helix L. (English ivy) can synthesize 16- and 18-carbon
monoene and diene products. J. Biol. Chem. 280: 28169-28176.

Ashok J, Marillia EF, Vivijan B, Michael GE, Cahoon EB, Kinney AJ, Taylor DC (2005)
Production of 22:2.5,13 and 20:1.5 in Brassica carinata and soybean breeding lines via
introduction of Limnanthes genes. Mol. Breeding 15: 157-167

Cahoon EB, Kinney AJ (2005) Production of vegetable oils with novel properties: using
genomic tools to probe and manipulate fatty acid metabolism. Eur. J. Lipid Sci. Technol. 107:
239-243.

Arkus K, Cahoon EB, Jez JM (2005) Kinetic characterization of wheat chlorophyllase reveals a
mechanistic connection to the carboxylesterase enzyme family. Arch. Biochem. Biophys. 438:
146-155.

Schmidt MA, Tucker DM, Cahoon EB, Parrott WA (2005) Towards normalization of soybean
somatic embryo maturation. Plant Cell Reports 24: 383-391.

Schmidt MA, Dietrich CR, Cahoon EB (2004) Biotechnological enhancement of soybean oil for
lubricant applications. In Synthetic, Mineral Oil, and Bio-Based Lubricants: Chemistry and
Technology (Ed. Rudnick L). CRC Press, Boca Raton, FL, pp 389-397.

Cahoon EB, Kinney AJ (2004) Dimorphecolic acid is synthesized by the coordinate activities of
two divergent .12-oleic acid desaturases. J. Biol. Chem. 279: 12495-12502

Cahoon EB, Hall SE, Ripp KG, Ganzke TS, Hitz WD, Coughlan SJ (2003) Metabolic redesign
of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content.
Nature Biotechnology 21: 1082-1087.

Cahoon EB (2003) Genetic enhancement of soybean oil for industrial uses: prospects and
challenges. Agbioforum 6: 11-13.

Sattler SE, Cahoon EB, Coughlan SJ, DellaPenna D (2003) Characterization of tocopherol
cyclases from higher plants and cyanobacteria. evolutionary implications for tocopherol
synthesis and function. Plant Physiol. 132: 2184-2195.

Cahoon EB, Schnurr JA, Huffman EA, Minto RE (2003) Fungal responsive fatty acid
acetylenases occur widely in evolutionarily distant plant families. Plant J. 34: 671-683.

Jaworski J, Cahoon EB (2003) Industrial oils from transgenic plants. Curr. Opin. Plant Biol. 6:
178-184.

Kinney AJ, Cahoon EB, Hitz WD (2002) Manipulating desaturase activities in transgenic crop
plants. Biochem. Soc. Trans. 30: 1099-1103.

Cahoon EB, Ripp KG, Hall SE, McGonigle B (2002) Transgenic production of epoxy fatty acids
by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed. Plant Physiol. 128: 615-624.

Cahoon EB, Ripp KG, Hall SE, Kinney AJ (2001) Formation of conjugated .8, .10 double bonds
by .12-oleic acid desaturase related enzymes: biosynthetic origin of calendic acid. J. Biol. Chem. 276: 2637-2643.

Mekhedov S, Cahoon EB, Ohlrogge J (2001) An unusual seed-specific 3-ketoacyl-ACP synthase
associated with the synthesis of petroselinic acid. Plant Mol. Biol. 47:507-518

Cahoon EB, Shanklin J (2000) Substrate-dependent mutant complementation to select fatty acid
desaturase variants for metabolic engineering of plant seed oils. Proc. Natl. Acad. Sci. USA 97:
12350-12355.

Cahoon EB, Marrillia EF, Stecca KL, Hall SE, Taylor DC, Kinney AJ (2000) Production of fatty
acid components of meadowfoam oil in somatic soybean embryos. Plant Physiol. 124: 243-251.

Cahoon EB, Carlson TJ, Ripp KG, Schweiger BJ, Cook GA, Hall SE, Kinney AJ (1999)
Biosynthetic origin of conjugated double bonds: production of fatty acid components of high-
value drying oils in transgenic soybean embryos. Proc. Natl. Acad. Sci. USA 96: 12395-12940.

Shanklin J, Cahoon EB (1998) Desaturation and related modification of fatty acids. Annu. Rev.
Plant Physiol. Plant Mol. Biol. 49: 611-641.

Cahoon EB, Salehuzzaman S, Shanklin J, Browse J (1998) A determinant of substrate specificity predicted from the acyl-acyl carrier protein desaturase of cat’s claw seed. Plant Physiol. 117: 593-598.

Cahoon EB, Lindqvist Y, Schneider G, Shanklin J (1997) Redesign of soluble fatty acid
desaturases from plants for altered substrate specificity and double bond position. Proc. Natl.
Acad. Sci. USA 94:4872-4877 (This article was featured in Science News, May 31, 1997.)

Cahoon EB, Coughlan SJ, Shanklin J (1997) Characterization of a structurally and functionally
diverged acyl-acyl carrier protein desaturase from milkweed seed. Plant Mol. Biol. 33:11061110.

Schultz DJ, Cahoon EB, Shanklin J, Craig R, Cox-Foster DL, Mumma RO, Medford JI (1996)
Expression of a .9 14:0-ACP fatty acid desaturase gene is necessary for the production of .5
anacardic acids found in pest-resistant geranium (Pelargonium xhortorum). Proc. Natl. Acad.
Sci. USA 93:8771-8775.

Cahoon EB, Mills LA, Shanklin J (1996) Modification of the fatty acid composition of
Escherichia coli by co-expression of a plant acyl-acyl carrier protein desaturase and ferredoxin.
J. Bacteriol. 178:936-939.

Cahoon EB, Dörmann P, Ohlrogge JB (1994) Petroselinic acid biosynthesis and production in
transgenic plants. Prog. Lipid Res. 33:155-163.

Cahoon EB, Becker CK, Shanklin J, Ohlrogge JB (1994) cDNAs for isoforms of the .9-stearoylacyl carrier protein desaturase from Thunbergia alata endosperm. Plant Physiol. 106:807-808.

Cahoon EB, Cranmer AM, Shanklin J, Ohlrogge JB (1994) .6 Hexadecenoic acid is synthesized
by the activity of a soluble .6 palmitoyl-acyl carrier protein desaturase in Thunbergia alata
endosperm. J. Biol. Chem. 269: 27519-27526.

Cahoon EB, Ohlrogge JB (1994) Apparent role of phosphatidylcholine in petroselinic acid
metabolism in developing Umbelliferae seed. Plant Physiol. 104: 845-855.

Cahoon EB, Ohlrogge JB (1994) Metabolic evidence for the involvement of a .4-palmitoyl-acyl
carrier protein desaturase in petroselinic acid synthesis in developing coriander endosperm and
transgenic tobacco cells. Plant Physiol. 104: 827-838. (Featured on cover of Plant Physiology,
March 1994)

Cahoon EB, Shanklin J, Ohlrogge JB (1992) Expression of a coriander desaturase results in
petroselinic acid production in transgenic tobacco. Proc. Natl. Acad. Sci. USA 89: 11184-11188.

Cahoon EB, Lynch DV (1991) Analysis of glucocerebrosides of rye (Secale cereale L. cv Puma)
leaf and plasma membrane. Plant Physiol. 95:58-68.

Patents:

Cahoon EB, Cahoon RE, Thorpe CJ (2007) Chlorophyllases. U.S. Patent # 7,199,284.

Cahoon EB, Coughlan SJ, Cahoon RE, Butler KH (2006) Compositions and methods for
altering tocotrienol content. US Patent # 7,154,029.

Cahoon EB (2006) Phospholipid:diacylglycerol acyltransferases. U.S. Patent # 7,053,269.

Cahoon EB (2006) Enzymes involved in petroselinic acid biosynthesis. U.S. Patent # 7,002,060.

Cahoon EB, Cahoon RE, Hitz WD, Kinney AJ (2005) Membrane-bound desaturases. U.S.
Patent # 6,864,077.

Shanklin J, Cahoon EB (2004) Mutant fatty acid desaturase. U.S. Patent # 6,686,186.

Cahoon EB (2004) Plant lipases. U.S. Patent # 6,673,988.

Cahoon EB, Hitz WD, Ripp KG (2003) Method for the production of calendic acid, a fatty acid
containing delta-8,10,12 conjugated double bonds and related fatty acids having a modification
at the delta-9 position. U.S. Patent # 6,593,514.

Cahoon EB, Cahoon RE, Hitz WD, Kinney AJ (2002) Acyl-CoA oxidase homologues. U.S.
Patent # 6,368,840.

Cahoon EB, Cahoon RE, Hitz WD, Rafalski JA (2001) Ornithine biosynthesis enzymes. U.S.
Patent # 6,242,256.

Cahoon EB, Shanklin J, Lindqvist Y, Schneider G (2000) Modified acyl-ACP desaturase. U.S.
Patent # 6,100,091.

Cahoon EB, Shanklin J, Lindqvist Y, Schneider G (1998) Modified acyl-ACP desaturase. U.S.
Patent # 5,888,790.

Cahoon EB, Shanklin J, Lindqvist Y, Schneider G (1998) Modified acyl-ACP desaturase. U.S.
Patent # 5,705,391.

Cahoon EB, Ohlrogge JB (1997) Methods and compositions relating to plant .6 palmitoyl-acyl
carrier protein desaturase. U.S. Patent # 5,654,402.

Cahoon EB, Ohlrogge JB (1997) Methods and compositions relating to plant palmitoyl-acyl
carrier protein desaturase. U.S. Patent # 5,614,400.

Ohlrogge JB, Cahoon EB, Shanklin J, Somerville CR (1995) Method for the production of
petroselinic acid and omega-12 hexadecenoic acid in transgenic plants. U.S. Patent # 5,430,134.

Selected Pending Patents:

Kinney AJ, Cahoon EB, Damude HG, Hitz WD, Kolar CW, Liu Z-B (2004) Production of very
long chain polyunsaturated fatty acids in oilseed crops. PCT WO 04/071467.

Cahoon EB, Cahoon RE, Coughlan SJ, Butler KH (2003) Compositions and methods for altering
tocotrienol content. PCT WO 03/082899.

Butler KH, Cahoon EB, Cahoon RE, Famodu OO, Hall SE (2003) Phospholipid:diacylglycerol
acyltransferases. PCT WO 03/052090.

Cahoon EB (2002) A cytochrome P450 enzyme associated with the synthesis of delta 12-epoxy
groups in fatty acids of plants. PCT WO 02/08269.

Cahoon EB, Cahoon RE, Thorpe CJ (2002) Chlorophyllases. PCT WO 02/029022.

Cahoon EB, Cahoon RE, Hitz WD, Kinney AJ, Ripp KG (2000) Lysophosphatidic acid
acetyltransferases. PCT WO 00/49156.

Cahoon EB, Carlson TJ, Hitz WD, Ripp KG (2000) Genes for plant fatty acid modifying
enzymes associated with conjugated double bond formation. PCT WO 00/11176.

Cahoon EB, Cahoon RE, Falco SC, Famodou OO, Orozco EM Jr. (2000) Plant NADP-specific
glutamate dehydrogenase. PCT WO 00/28006.

Cahoon EB, Cahoon RE, Falco SC (2000) Plant SYR2 homologs. PCT WO 00/31142.

Cahoon EB, Kinney AJ, Cahoon RE (2000) Plant diacyglycerol acyltransferases. PCT WO
00/32756.

Cahoon EB, Cahoon RE, Hitz WD, Kinney AJ (2000) Membrane-bound desaturases. PCT WO
00/32790.

Cahoon EB, Cahoon RE, Kinney AJ, Rafalski JA (1999) LCB2 subunit of serine
palmitoyltransferase. PCT WO 99/49021.

Cahoon EB, Hitz WD, Kinney AJ, Vollmer SJ (1999) Limnanthes oil genes. PCT WO 99/49050.

Cahoon EB, Cahoon RE, Kinney AJ, Rafalski JA (1999) Triacylglycerol lipases. PCT WO
99/55883. 

 

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