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Publications
Cahoon EB, Shockey JM, Dietrich CR, Gidda SK, Mullen RT, Dyer JM (2007)
Engineering
oilseeds for sustainable production of industrial and nutritional
feedstocks: solving bottlenecks in
fatty acid flux. Curr. Opin. Plant. Biol. 10: 236-244
Hunter SC, Cahoon EB (2007) Enhancing vitamin E in oilseeds: unraveling
tocopherol and
tocotrienol biosynthesis. Lipids 42: 97-108.
Chen M, Han G, Dietrich CR, Dunn TM, Cahoon EB (2006) The essential
nature of
sphingolipids in plants as revealed by the functional identification and
characterization of the
Arabidopsis LCB1 subunit of serine palmitoyltransferase. Plant Cell 18:
3576-3593.
Lohman A, Schottler MA, Brehelin C, Kessler F, Block R, Cahoon EB,
Dörmann P (2006)
Deficiency in phylloquinone (vitamin K1) methylation affects
prenylquinine distribution,
photosystem I abundance and anthocyanin accumulation in the Arabidopsis
AtmenG mutant. J.
Biol. Chem. 281: 40461-40472.
Kaewsuwan S, Cahoon EB, Perroud P-F, Wiwat C, Panvisavas N, Quatrano RS,
Cove DJ,
Bunyapraphatsaran N (2006) Identification and functional
characterization of the moss
Physcomitrella patens (Hedw.) B.S.G. .5-desaturase gene involved in
arachidonic and
eicosapentaenoic acids biosynthesis. J. Biol. Chem. 281:21988-21997.
Cahoon EB, Dietrich CR, Meyer K, Damude HG, Dyer JM, Kinney AJ (2006)
Conjugated fatty
acids accumulate to high levels in phospholipids of metabolically
engineered soybean and
Arabidopsis seeds. Phytochemistry 67: 1166-1176.
Markham JM, Li J, Cahoon EB, Jaworski JG (2006) Plant sphingolipids:
separation and
identification of major sphingolipid classes from leaves. J. Biol. Chem.
281: 22684-94.
Eckert H, LaVallee B, Schweiger BJ, Kinney AJ, Cahoon EB, Clemente T
(2006) Co-expression
of the borage .6 desaturase and the Arabidopsis .15 desaturase results
in high accumulation of
stearidonic acid in the seeds of transgenic soybean. Planta 224:
1116-1128.
Paul S, Gable K, Beaudoin F, Cahoon E, Jaworski J, Napier JA, Dunn TM
(2006)
Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family
substitute for the
elop proteins of Saccharomyces cerevisiae. J. Biol. Chem. 281:
9018-9029.
Whittle E, Cahoon EB, Subrahmanyam S, Shanklin J (2005) A
multifunctional acyl-acyl carrier
protein desaturase from Hedera helix L. (English ivy) can synthesize 16-
and 18-carbon
monoene and diene products. J. Biol. Chem. 280: 28169-28176.
Ashok J, Marillia EF, Vivijan B, Michael GE, Cahoon EB, Kinney AJ,
Taylor DC (2005)
Production of 22:2.5,13 and 20:1.5 in Brassica carinata and soybean
breeding lines via
introduction of Limnanthes genes. Mol. Breeding 15: 157-167
Cahoon EB, Kinney AJ (2005) Production of vegetable oils with novel
properties: using
genomic tools to probe and manipulate fatty acid metabolism. Eur. J.
Lipid Sci. Technol. 107:
239-243.
Arkus K, Cahoon EB, Jez JM (2005) Kinetic characterization of wheat
chlorophyllase reveals a
mechanistic connection to the carboxylesterase enzyme family. Arch.
Biochem. Biophys. 438:
146-155.
Schmidt MA, Tucker DM, Cahoon EB, Parrott WA (2005) Towards
normalization of soybean
somatic embryo maturation. Plant Cell Reports 24: 383-391.
Schmidt MA, Dietrich CR, Cahoon EB (2004) Biotechnological enhancement
of soybean oil for
lubricant applications. In Synthetic, Mineral Oil, and Bio-Based
Lubricants: Chemistry and
Technology (Ed. Rudnick L). CRC Press, Boca Raton, FL, pp 389-397.
Cahoon EB, Kinney AJ (2004) Dimorphecolic acid is synthesized by the
coordinate activities of
two divergent .12-oleic acid desaturases. J. Biol. Chem. 279:
12495-12502
Cahoon EB, Hall SE, Ripp KG, Ganzke TS, Hitz WD, Coughlan SJ (2003)
Metabolic redesign
of vitamin E biosynthesis in plants for tocotrienol production and
increased antioxidant content.
Nature Biotechnology 21: 1082-1087.
Cahoon EB (2003) Genetic enhancement of soybean oil for industrial uses:
prospects and
challenges. Agbioforum 6: 11-13.
Sattler SE, Cahoon EB, Coughlan SJ, DellaPenna D (2003) Characterization
of tocopherol
cyclases from higher plants and cyanobacteria. evolutionary implications
for tocopherol
synthesis and function. Plant Physiol. 132: 2184-2195.
Cahoon EB, Schnurr JA, Huffman EA, Minto RE (2003) Fungal responsive
fatty acid
acetylenases occur widely in evolutionarily distant plant families.
Plant J. 34: 671-683.
Jaworski J, Cahoon EB (2003) Industrial oils from transgenic plants.
Curr. Opin. Plant Biol. 6:
178-184.
Kinney AJ, Cahoon EB, Hitz WD (2002) Manipulating desaturase activities
in transgenic crop
plants. Biochem. Soc. Trans. 30: 1099-1103.
Cahoon EB, Ripp KG, Hall SE, McGonigle B (2002) Transgenic production of
epoxy fatty acids
by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed.
Plant Physiol. 128: 615-624.
Cahoon EB, Ripp KG, Hall SE, Kinney AJ (2001) Formation of conjugated
.8, .10 double bonds
by .12-oleic acid desaturase related enzymes: biosynthetic origin of
calendic acid. J. Biol. Chem. 276: 2637-2643.
Mekhedov S, Cahoon EB, Ohlrogge J (2001) An unusual seed-specific
3-ketoacyl-ACP synthase
associated with the synthesis of petroselinic acid. Plant Mol. Biol.
47:507-518
Cahoon EB, Shanklin J (2000) Substrate-dependent mutant complementation
to select fatty acid
desaturase variants for metabolic engineering of plant seed oils. Proc.
Natl. Acad. Sci. USA 97:
12350-12355.
Cahoon EB, Marrillia EF, Stecca KL, Hall SE, Taylor DC, Kinney AJ (2000)
Production of fatty
acid components of meadowfoam oil in somatic soybean embryos. Plant
Physiol. 124: 243-251.
Cahoon EB, Carlson TJ, Ripp KG, Schweiger BJ, Cook GA, Hall SE, Kinney
AJ (1999)
Biosynthetic origin of conjugated double bonds: production of fatty acid
components of high-
value drying oils in transgenic soybean embryos. Proc. Natl. Acad. Sci.
USA 96: 12395-12940.
Shanklin J, Cahoon EB (1998) Desaturation and related modification of
fatty acids. Annu. Rev.
Plant Physiol. Plant Mol. Biol. 49: 611-641.
Cahoon EB, Salehuzzaman S, Shanklin J, Browse J (1998) A determinant of
substrate specificity predicted from the acyl-acyl carrier protein
desaturase of cat’s claw seed. Plant Physiol. 117: 593-598.
Cahoon EB, Lindqvist Y, Schneider G, Shanklin J (1997) Redesign of
soluble fatty acid
desaturases from plants for altered substrate specificity and double
bond position. Proc. Natl.
Acad. Sci. USA 94:4872-4877 (This article was featured in Science News,
May 31, 1997.)
Cahoon EB, Coughlan SJ, Shanklin J (1997) Characterization of a
structurally and functionally
diverged acyl-acyl carrier protein desaturase from milkweed seed. Plant
Mol. Biol. 33:11061110.
Schultz DJ, Cahoon EB, Shanklin J, Craig R, Cox-Foster DL, Mumma RO,
Medford JI (1996)
Expression of a .9 14:0-ACP fatty acid desaturase gene is necessary for
the production of .5
anacardic acids found in pest-resistant geranium (Pelargonium xhortorum).
Proc. Natl. Acad.
Sci. USA 93:8771-8775.
Cahoon EB, Mills LA, Shanklin J (1996) Modification of the fatty acid
composition of
Escherichia coli by co-expression of a plant acyl-acyl carrier protein
desaturase and ferredoxin.
J. Bacteriol. 178:936-939.
Cahoon EB, Dörmann P, Ohlrogge JB (1994) Petroselinic acid biosynthesis
and production in
transgenic plants. Prog. Lipid Res. 33:155-163.
Cahoon EB, Becker CK, Shanklin J, Ohlrogge JB (1994) cDNAs for isoforms
of the .9-stearoylacyl carrier protein desaturase from Thunbergia alata
endosperm. Plant Physiol. 106:807-808.
Cahoon EB, Cranmer AM, Shanklin J, Ohlrogge JB (1994) .6 Hexadecenoic
acid is synthesized
by the activity of a soluble .6 palmitoyl-acyl carrier protein
desaturase in Thunbergia alata
endosperm. J. Biol. Chem. 269: 27519-27526.
Cahoon EB, Ohlrogge JB (1994) Apparent role of phosphatidylcholine in
petroselinic acid
metabolism in developing Umbelliferae seed. Plant Physiol. 104: 845-855.
Cahoon EB, Ohlrogge JB (1994) Metabolic evidence for the involvement of
a .4-palmitoyl-acyl
carrier protein desaturase in petroselinic acid synthesis in developing
coriander endosperm and
transgenic tobacco cells. Plant Physiol. 104: 827-838. (Featured on
cover of Plant Physiology,
March 1994)
Cahoon EB, Shanklin J, Ohlrogge JB (1992) Expression of a coriander
desaturase results in
petroselinic acid production in transgenic tobacco. Proc. Natl. Acad.
Sci. USA 89: 11184-11188.
Cahoon EB, Lynch DV (1991) Analysis of glucocerebrosides of rye (Secale
cereale L. cv Puma)
leaf and plasma membrane. Plant Physiol. 95:58-68.
Patents:
Cahoon EB, Cahoon RE,
Thorpe CJ (2007) Chlorophyllases. U.S. Patent # 7,199,284.
Cahoon EB, Coughlan SJ, Cahoon RE, Butler KH (2006) Compositions and
methods for
altering tocotrienol content. US Patent # 7,154,029.
Cahoon EB (2006) Phospholipid:diacylglycerol acyltransferases. U.S.
Patent # 7,053,269.
Cahoon EB (2006) Enzymes involved in petroselinic acid biosynthesis.
U.S. Patent # 7,002,060.
Cahoon EB, Cahoon RE, Hitz WD, Kinney AJ (2005) Membrane-bound
desaturases. U.S.
Patent # 6,864,077.
Shanklin J, Cahoon EB (2004) Mutant fatty acid desaturase. U.S. Patent #
6,686,186.
Cahoon EB (2004) Plant lipases. U.S. Patent # 6,673,988.
Cahoon EB, Hitz WD, Ripp KG (2003) Method for the production of calendic
acid, a fatty acid
containing delta-8,10,12 conjugated double bonds and related fatty acids
having a modification
at the delta-9 position. U.S. Patent # 6,593,514.
Cahoon EB, Cahoon RE, Hitz WD, Kinney AJ (2002) Acyl-CoA oxidase
homologues. U.S.
Patent # 6,368,840.
Cahoon EB, Cahoon RE, Hitz WD, Rafalski JA (2001) Ornithine biosynthesis
enzymes. U.S.
Patent # 6,242,256.
Cahoon EB, Shanklin J, Lindqvist Y, Schneider G (2000) Modified acyl-ACP
desaturase. U.S.
Patent # 6,100,091.
Cahoon EB, Shanklin J, Lindqvist Y, Schneider G (1998) Modified acyl-ACP
desaturase. U.S.
Patent # 5,888,790.
Cahoon EB, Shanklin J, Lindqvist Y, Schneider G (1998) Modified acyl-ACP
desaturase. U.S.
Patent # 5,705,391.
Cahoon EB, Ohlrogge JB (1997) Methods and compositions relating to plant
.6 palmitoyl-acyl
carrier protein desaturase. U.S. Patent # 5,654,402.
Cahoon EB, Ohlrogge JB (1997) Methods and compositions relating to plant
palmitoyl-acyl
carrier protein desaturase. U.S. Patent # 5,614,400.
Ohlrogge JB, Cahoon EB, Shanklin J, Somerville CR (1995) Method for the
production of
petroselinic acid and omega-12 hexadecenoic acid in transgenic plants.
U.S. Patent # 5,430,134.
Selected Pending Patents:
Kinney AJ, Cahoon EB, Damude HG, Hitz WD,
Kolar CW, Liu Z-B (2004) Production of very
long chain polyunsaturated fatty acids in oilseed crops. PCT WO
04/071467.
Cahoon EB, Cahoon RE, Coughlan SJ, Butler KH (2003) Compositions and
methods for altering
tocotrienol content. PCT WO 03/082899.
Butler KH, Cahoon EB, Cahoon RE, Famodu OO, Hall SE (2003)
Phospholipid:diacylglycerol
acyltransferases. PCT WO 03/052090.
Cahoon EB (2002) A cytochrome P450 enzyme associated with the synthesis
of delta 12-epoxy
groups in fatty acids of plants. PCT WO 02/08269.
Cahoon EB, Cahoon RE, Thorpe CJ (2002) Chlorophyllases. PCT WO
02/029022.
Cahoon EB, Cahoon RE, Hitz WD, Kinney AJ, Ripp KG (2000)
Lysophosphatidic acid
acetyltransferases. PCT WO 00/49156.
Cahoon EB, Carlson TJ, Hitz WD, Ripp KG (2000) Genes for plant fatty
acid modifying
enzymes associated with conjugated double bond formation. PCT WO
00/11176.
Cahoon EB, Cahoon RE, Falco SC, Famodou OO, Orozco EM Jr. (2000) Plant
NADP-specific
glutamate dehydrogenase. PCT WO 00/28006.
Cahoon EB, Cahoon RE, Falco SC (2000) Plant SYR2 homologs. PCT WO
00/31142.
Cahoon EB, Kinney AJ, Cahoon RE (2000) Plant diacyglycerol
acyltransferases. PCT WO
00/32756.
Cahoon EB, Cahoon RE, Hitz WD, Kinney AJ (2000) Membrane-bound
desaturases. PCT WO
00/32790.
Cahoon EB, Cahoon RE, Kinney AJ, Rafalski JA (1999) LCB2 subunit of
serine
palmitoyltransferase. PCT WO 99/49021.
Cahoon EB, Hitz WD, Kinney AJ, Vollmer SJ (1999) Limnanthes oil genes.
PCT WO 99/49050.
Cahoon EB, Cahoon RE, Kinney AJ, Rafalski JA (1999) Triacylglycerol
lipases. PCT WO
99/55883.
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