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Publications
Click on a PDF icon to view reprints
Donald Danforth Plant Science Center (2002-Present)
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56. Yu O, Jez JM (2008) Nature’s assembly line:
biosynthesis of simple phenylpropanoids and plant
polyketides. Plant J. (in press)
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55. Jez JM, Fukagawa NK (2008) Plant sulfur compounds
and human health In Sulfur: A Missing
Link Between Soils, Crops, and Nutrition (Jez JM, Ed.),
ASA-CSSA-SSSA Publiishing, Madison, WI (in press)
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54. Arkus KAJ, Jez JM (2008) An integrated protein
chemistry lab module: choloropyll and chlorophyllase.
Biochem. Mol. Biol. Educ. (in press)
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53. Zubieta C, Arkus KAJ, Cahoon
RE, Jez JM (2008) A single amino acid change is responsible
for evolution of acyltransferase specificity in bacterial
methionine biosynthesis. J. Biol. Chem. (in
press)
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52. Kumaran S, Francois JA,
Krishnan HB, Jez JM (2008) Regulatory protein-protein
interactions in primary metabolism: the case of the cysteine
synthase complex In Sulfur Assimilation
and Abiotic Stress in Plants (NA Khan, RP Singh, Eds),
pp. 97-109, Springer-Verlag, NY
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51. Phartiyal P, Kim WS, Cahoon
RE, Jez JM, Krishnan HB (2008) The role of 5’-adenylylsulfate
reductase in the sulfur assimilation pathway of soybean:
molecular cloning, gene expression, and kinetic
characterization. Phytochemistry 69,
356-364
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50. Jez JM, Schachtman DP, Berg RH, Taylor CG, Chen S,
Hicks LM, Jaworski JG, Smith TJ, Nielsen E, Pikaard CS
(2007) Developing a new
interdisciplinary lab course for undergraduate and
graduate students: plant cells and proteins.
Biochem. Mol. Biol. Educ. 35, 410-415
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49. Hicks LM, Cahoon RE, Bonner ER, Rivard RS, Sheffield J, Jez JM
(2007) Thiol-based regulation of redox-active glutamate-cysteine
ligase from Arabidopsis thaliana. Plant Cell 19, 2653-2661 |
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48.
Herrera K, Cahoon RE, Kumaran S, Jez JM (2007) Reaction
mechanism of glutathione synthetase from Arabidopsis
thaliana: site-directed mutagenesis of active site
residues. J. Biol. Chem. 282,
17157-17165 |
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47. Fu CJ, Jez JM, Kerley MS,
Allee GL, Krishnan HB (2007) Identification,
characterization, epitope mapping, and three-dimensional
modeling of alpha-subunit of beta-conglycinin of
soybean, a potential allergen for young pigs. J. Agric. Food
Chem. 55, 4014-4020 |
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46. Kumaran S, Jez JM (2007) Thermodynamics of the interaction between O-acetylserine sulfhydrylase and the C-terminus of serine acetyltransferase.
Biochemistry 46, 5586-5594 |
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45. Shin R, Alvarez S, Burch AY, Jez JM, Schachtman DP (2007) Phosphoproteomic identification of targets of the
Arabidopsis sucrose nonfermenting-like kinase SnRK2.8 reveals a connection to metabolic processes.
Proc. Natl. Acad. Sci. USA 104, 6460-6465 |
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44. Brendza KM, Haakenson W, Cahoon RE, Hicks LM, Palavalli LH, Chiapelli B, McLaird M, McCarter JP, Williams DJ, Hresko MC, Jez JM (2007) Phosphoethanolamine N-methyltransferase (PMT-1) catalyzes the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans.
Biochem. J. 404, 439-448 |
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43. Jez JM (2007) Phosphatidylcholine biosynthesis as a
potential target for inhibition of metabolism in parasitic
nematodes. Curr. Enz. Inhib. 3, 133-142 |
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42. Francois JA, Kumaran S, Jez JM (2006) Structural basis for
interaction of O-acetylserine sulfhydrylase and serine
acetyltransferase in the Arabidopsis cysteine synthase
complex. Plant Cell 18, 3647-3655 |
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41. Zhang Y, Li SZ, Pan X, Cahoon RE, Jaworski JG, Wang X, Jez JM, Chen F, Yu O
(2006) Using unnatural protein fusions to engineer resveratrol biosynthesis in
yeast and mammalian cells. J. Am. Chem.
Soc. 128, 13030-13031 |
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40. Romanyuk ND, Rigden DJ, Vatamaniuk
OK, Lang A, Cahoon RE, Jez JM, Rea PA (2006) Mutagenic
definition of papain-like catalytic triad and sufficiency of
N-terminal domain for single-site enzyme acylation and core
catalysis by an eukaryotic phytochelatin synthase. Plant
Physiol. 141, 858-869 |
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39. Phartiyal P, Kim WS, Cahoon RE, Jez
JM, Krishnan HB (2006) Soybean ATP sulfurylase, a homodimeric
enzyme involved in sulfur assimilation, is abundantly
expressed in roots and induced by cold treatment. Arch.
Biochem. Biophys. 450, 20-29 |
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38. Arkus KAJ, Jez JM (2006) Development
of a high-throughput purification method and a continuous
assay for chlorophyllase. Anal. Biochem. 353,
93-98
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37. Palavalli LH, Brendza KM, Haakenson
W, Cahoon RE, McLaird M, Hicks LM, McCarter JP, Williams DJ,
Hresko MC, Jez JM (2006) Defining the role of
phosphomethylethanolamine N-methyltransferase from
Caenorhabditis elegans in phosphocholine biosynthesis by
biochemical and kinetic analysis. Biochemistry 45,
6056-6065
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36. Bonner ER, Cahoon RE, Knapke SM, Jez JM (2005) Molecular basis of plantcysteine biosynthesis: structural and functional analysis of O-acetylserinesulfhydrylase from Arabidopsis thaliana. J. Biol. Chem. 280: 38803-38813
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35. Arkus KAJ,
Cahoon EB, Jez JM (2005)
Mechanistic analysis of wheat
chlorophyllase. Arch. Biochem.
Biophys. 438, 146-155 |
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34. Jez JM, Cahoon RE (2004) Kinetic mechanism of glutathione synthetase from
Arabidopsis
thaliana. J.
Biol. Chem. 279, 42726-42731 |
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33. Jez JM, Cahoon RE, Chen S (2004) Arabidopsis thaliana glutamate-cysteine
ligase: functional properties, kinetic mechanism, and regulation of activity.
J.
Biol. Chem. 279, 33463-33470 |
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Kosan Biosciences, Inc. (2001-2002)
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32. Jez JM, Chen JC, Rastelli J, Stroud RM, Santi DV (2003) Crystal structure and
molecular modeling of 17-DMAG in complex with the N-terminal domain of human hsp90. Chem. Biol
10, 361-368 |
Post-doctoral work (Salk Institute 1998-2001)
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31. Jez JM, Bowman ME, Noel JP (2002) Expanding the biosynthetic repertoire of type
III polyketide synthases by altering starter molecule specificity. Proc. Natl. Acad.Sci. USA 99, 5319-5324 |
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30. Jez JM, Bowman ME, Noel JP (2002) The role of hydrogen bonds in the reaction
mechanism of chalcone isomerase. Biochemistry 41, 5168-5176 |
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29. Jez JM, Noel JP (2002) Reaction mechanism of chalcone isomerase: pH- dependence, diffusion control, and product binding differences. J. Biol. Chem. 277, 1361-1369 |
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28. Noel JP, Jez JM, Austin MB, Bowman ME, Ferrer JL (2002) Structurally guided
alteration of biosynthesis in plant type III polyketide synthases in Recent Advances in Phytochemistry Vol. 36 – Phytochemistry in the Genomics and Post-Genomics Era (JT Romeo, ed.) pp. 197-222, Plenum Press, New York |
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27. Jez JM, Ferrer JL, Bowman ME, Austin MB, Schröder J, Dixon RA, Noel JP (2001) Structure and mechanism of chalcone synthase-like polyketide synthases. J. Ind. Micro. Biotech. 27, 393-398 |
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26. Jez JM, Bowman ME, Noel JP (2001) Structure-guided programming of polyketide chain-length determination in chalcone synthase. Biochemistry 49, 14829- 14838 |
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25. Mallis RJ, Bruzin K, Jez JM, Wilson EK, Dieckmann GR, Robic S, Harrahy J (2001) Proteins: the complete works. Trends Biochem. Sci. 26, 642-643 |
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24. Penning TM, Jez JM (2001) Enzyme redesign. Chem. Rev. 101, 3027-3046 |
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23. Jez JM, Noel JP (2000) Mechanism of chalcone synthase: pKa of the catalytic cysteine and the role of the conserved histidine in a plant-specific polyketide synthase. J. Biol. Chem. 275, 39640-39646 |
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22. Jez JM, Austin MB, Ferrer J-L, Bowman ME, Schröder J, Noel JP (2000) Structural control of polyketide formation in plant-specific polyketide synthases. Chem. Biol. 7, 919-930 |
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21. Jez JM, Bowman ME, Dixon RA, Noel JP (2000) Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nature Struct. Biol. 7, 786-791 |
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20. Jez JM, Noel JP (2000) A kaleidoscope of carotenoids. Nature Biotech. 18, 825- 826 |
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19. Jez JM, Ferrer J-L, Bowman ME, Dixon RA, Noel JP (2000) Dissection of malonyl-CoA decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry 39, 890-902 |
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18. Ferrer J-L, Jez JM, Bowman ME, Dixon RA, Noel JP (1999) Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Nature Struct. Biol. 6, 775-784 |
Graduate work (University of Pennsylvania, 1992-1998)
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17. Penning TM, Ma H, Jez JM (2001) Engineering steroid hormone specificity into aldo-keto reductases. Chem. Biol. Interact. 130-132, 659-671 |
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16. Jez JM, Penning TM (2001) The aldo-keto reductase superfamily: an update. Chem. Biol. Interact. 130-132, 499-525 |
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15. Penning TM, Burczynski ME, Jez JM, Lin H-K, Ma H, Moore M, Ratnam K, Palackal N (2001) Structure-function aspects and inhibitor design of type 5 17ß- hydroxysteroid dehydrogenase (AKR1C3). Mol. Cell. Endocrinol. 171, 137-149 |
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14. Penning TM, Burczynski ME, Jez JM, Hung C-F, Lin H-K, Ma H, Moore M, Palackal N, Ratnam K (2000) Human 3a-hydroxysteroid dehydrogenase isoforms (AKR1C1-1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation sex hormones. Biochem. J. 351, 67-77 |
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13. Jez JM, Penning TM (1998) Engineering steroid 5ß-reductase activity into rat liver 3a-hydroxysteroid dehydrogenase. Biochemistry 37, 9695-9703 |
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12. Schlegel BP, Jez JM, Penning TM (1998) Mutagenesis of 3a-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases. Biochemistry 37, 3538-3548 |
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11. Penning TM, Lin H-K, Jez JM, Ricigliano JW (1997) Inhibition of type 3 3a-hydroxysteroid dehydrogenase in Emerging Therapeutic Targets, Vol. 1: Oncologic, Endocrine, & Metabolic (A Ward, ed.) pp. 141-145, Ashley Publications Ltd., London |
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10. Jez JM*, Lin H-K*, Schlegel BP, Peehl DM, Pachter JA, Penning TM (1997) Expression and characterization of recombinant type 2 3a-hydroxysteroid dehydrogenase from human prostate: Demonstration of bifunctional 3a/17ß-HSD activity and cellular distribution. Mol. Endocrinol. 11, 1971-1984 (*equal contribution) |
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9. Jez JM, Flynn TG, Penning TM (1997) A new nomenclature for the aldo-keto reductase superfamily. Biochem. Pharmacol. 54, 639-647 |
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8. Jez JM, Bennett MJ, Schlegel BP, Lewis M, Penning TM (1997) Comparative anatomy of the aldo-keto reductase superfamily. Biochem. J. 326, 625-636 |
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7. Bennett MJ, Albert RH, Jez JM, Ma H, Penning TM, Lewis M (1997) Steroid recognition and regulation of hormone action: structure of testosterone and NADP+ bound to 3a-hydroxysteroid/dihydrodiol dehydrogenase. Structure 5, 799-812 |
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6. Penning TM, Bennett MJ, Smith-Hoog S, Schlegel BP, Jez JM, Lewis M (1997) Structure and function of rat 3a-hydroxysteroid dehydrogenase. Steroids 62, 101-111 |
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5. Jez JM, Flynn TG, Penning TM (1996) A proposed nomenclature system for the aldo-keto reductase superfamily in Enzymology and Molecular Biology of Carbonyl Metabolism 6 (H Weiner, R Lindahl, DW Crabb, & TG Flynn, eds.) pp. 579-589, Plenum Press, New York |
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4. Jez JM, Schlegel BP, Penning TM (1996) Characterization of the substrate binding pocket in rat liver 3a-hydroxysteroid/dihydrodiol dehydrogenase: the roles of tryptophans in ligand recognition and protein fluorescence. J. Biol. Chem. 271, 30190-30198 |
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3. Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M (1996) Structure of 3a-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+. Biochemistry 35, 10702-10711 |
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2. Penning TM, Pawlowski JE, Schlegel BP, Jez JM, Lin H-K, Hoog SS, Bennett MJ, Lewis M (1996) Mammalian 3a-hydroxysteroid dehydrogenases. Steroids 61, 508-523 |
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1. Jez JM, Vanderkooi JM, Laties AM (1996) Spectroscopic characterization of bendazac and benzydamine: possible photochemical modes of action. Biochem. Biophys. Res. Comm. 221, 266-270 |
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